Bee Venom Therapy: a Sting in the Tale of Rheumatoid Arthritis?
Keywords:
MedicineReferences
1.Son DJ, Lee JW, Lee YH, Song HS, Lee CK, Hong JT. Therapeutic application of
anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharm. Therap. 2007;115:246–270.
2.Lee MS, Pittler MH, Shin BC, Kong JC. Bee Venom Acupuncture for Musculoskeletal Pain: A Review. Journal of Pain. 2008;9(4):289–297.
3.Kim YS, Jun H, Chae Y, Park HJ, Kim BH, Chang IM, Kang SK, Lee HJ. The
practice of Korean medicine: An overview of clinical trials in acupuncture. Evid
Based Complement Alternat Med 2005;2:325–352.
4.Lee JD, Park HJ, Chae Y, Lim S. An overview of bee venom acupuncture in the
treatment of arthritis. Evid Based Complement Alternat Med 2005;2:79–84.
5.Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, Kang SK, Beitz AJ, Lee JH. Bee
venom injection into an acupuncture point reduces arthritis associated edema and
nociceptive responses. Pain 2001;90:271–280.
6.Kwon YB, Kang MS, Kim HW, Ham TW, Yim YK, Jeong SH, Park DS, Choi
DY, Han HJ, Beitz AJ, Lee JH. Antinociceptive effects of bee venom acupuncture
(apipuncture) in rodent animal models: A comparative study of acupoint versus
non-acupoint stimulation. Acupunct Electrother Res 2001;26:59–68.
7.Robbins SL, Cotran RS, Kumar V, Collins T. Pocket Companion to Pathologic
Basis of Disease. 6th Ed. Pennsylvania: WB Saunders Company; 1999.
8.Tak PP, Bresnihan B. The pathogenesis and prevention of joint damage in
rheumatoid arthritis: advances from synovial biopsy and tissue analysis. Arthritis
Rheum. 2000;43(12):2619−2633.
9.Van der Kraan PM, van den Berg WB. Osteophytes; relevance and biology. Osteoarthritis Cartilage. 2007;15(3):237–44.
10.Williams JA, Shacter E. Regulation of macrophage cytokine production by
prostaglandin E2. Distinct roles of cyclooxygenase-1 and -2. J. Biol. Chem.
1997;272(41):25693−25699.
11. Pap T, Müller-Ladner U, Gay RE, Gay S. Fibroblast biology: Role of synovial
fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. 2000;2:361–
367.
12.Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland, JP,
et al. Impaired inflammatory and pain responses in mice lacking an inducible
prostaglandin E synthase. Proc. Natl. Acad. Sci. USA. 2003;100(15):9044−9049.
13.Green JA, Smith GM, Buchta R, Lee R, Ho KY, Rajkovic IA, et al. Circulating
phospholipase A2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis. Inflammation.
1991;15(5);355−367.
14.Bomalaski JS, Baker D, Resurreccion NV, Clark MA. Rheumatoid arthritis synovial fluid phospholipase A2 activating protein (PLAP) stimulates human neutrophil degranulation and superoxide ion production. Agents Actions.
1989:27(3-4);425−427.
15.Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J. Immunol.
1995;154(8):4027−4031.
16.Pope RM. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nature Reviews Immunology. 2002;2:527–535
17.Gauldie J, Hanson JM, Rumjanek FD, Shipolini RA, Vernon CA. The peptide
components of bee venom. Eur. J. Biochem. 1975;61:369–376.
18.Shier WT. Activation of high levels of endogenous phospholipase A2 in cultured
cells. Proc. Natl. Acad. Sci. USA. 1979;76(1):195−199.
19.Koburova KL, Michailova SG, Shkenderov SV. Further investigation on the
anti-inflammatory properties of adolapin-bee venom polypeptide. Acta. Physiol.
Pharmacol. Bulg. 1985;11(2):50−55.
20.Nam KW, Je KH, Lee JH, Han HJ, Lee HJ, Kang SK, et al. Inhibition of COX-2
activity and proinflammatory cytokines (TNFalpha and IL-1beta) production by
water-soluble sub-fractionated parts from bee (Apis mellifera) venom. Arch. Pharm.
Res. 2003;26(5):383−388.
21.Park HJ, Lee SH, Son DJ, Oh KW, Kim KH, Song HS, et al. Anti-arthritic effect
of bee venom: inhibition of inflammation mediator generation by suppression of
NF-kappaB through interaction with the p50 subunit. Arthritis Rheum.
2004;50(11):3504−3515.
22.Hong SJ, Rim GS, Yang HI, Yin CS, Koh HG, Jang MH, et al. Bee venom induces apoptosis through caspase-3 activation in synovial fibroblasts of patients
with rheumatoid arthritis. Toxicon. 2005;46(1):39−45.
23.Loeser JD, Treede RD. The Kyoto protocol of IASP Basic Pain Terminology.
Pain 137 2008;3: 473–477.
24.Furst S. Transmitters involved in antinociception in the spinal cord. Brain Res.
1999;48(2):129−141.
25.Baron R. Mechanisms of disease: Neuropathic pain – a clinical perspective. Nature Clin. Pract. Neuro. 2006;2:95–106.
26.Lee JD, Park HJ, Chae Y, Lim S. An overview of bee venom acupuncture in the
treatment of arthritis. Evid. Based Complement Alternat. Med. 2005;2:79–84.
27.Kwon YB, Kang MS, Kim HW, Ham TW, Yim YK, Jeong SH, et al. Anti-nociceptive effects of bee venom acupuncture (apipuncture) in rodent animal models: a
comparative study of acupoint versus non-acupoint stimulation. Acupunct. Electrother. Res. 2001(b);26(1-2):59−68.
28.Baek YH, Huh JE, Lee JD, Choi do Y, Park DS. Antinociceptive effect and the
mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the
rat model of collagen-induced arthritis: mediation by alpha2-Adrenoceptors. Brain
Res. 2006;1073-1074:305−310.
anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharm. Therap. 2007;115:246–270.
2.Lee MS, Pittler MH, Shin BC, Kong JC. Bee Venom Acupuncture for Musculoskeletal Pain: A Review. Journal of Pain. 2008;9(4):289–297.
3.Kim YS, Jun H, Chae Y, Park HJ, Kim BH, Chang IM, Kang SK, Lee HJ. The
practice of Korean medicine: An overview of clinical trials in acupuncture. Evid
Based Complement Alternat Med 2005;2:325–352.
4.Lee JD, Park HJ, Chae Y, Lim S. An overview of bee venom acupuncture in the
treatment of arthritis. Evid Based Complement Alternat Med 2005;2:79–84.
5.Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, Kang SK, Beitz AJ, Lee JH. Bee
venom injection into an acupuncture point reduces arthritis associated edema and
nociceptive responses. Pain 2001;90:271–280.
6.Kwon YB, Kang MS, Kim HW, Ham TW, Yim YK, Jeong SH, Park DS, Choi
DY, Han HJ, Beitz AJ, Lee JH. Antinociceptive effects of bee venom acupuncture
(apipuncture) in rodent animal models: A comparative study of acupoint versus
non-acupoint stimulation. Acupunct Electrother Res 2001;26:59–68.
7.Robbins SL, Cotran RS, Kumar V, Collins T. Pocket Companion to Pathologic
Basis of Disease. 6th Ed. Pennsylvania: WB Saunders Company; 1999.
8.Tak PP, Bresnihan B. The pathogenesis and prevention of joint damage in
rheumatoid arthritis: advances from synovial biopsy and tissue analysis. Arthritis
Rheum. 2000;43(12):2619−2633.
9.Van der Kraan PM, van den Berg WB. Osteophytes; relevance and biology. Osteoarthritis Cartilage. 2007;15(3):237–44.
10.Williams JA, Shacter E. Regulation of macrophage cytokine production by
prostaglandin E2. Distinct roles of cyclooxygenase-1 and -2. J. Biol. Chem.
1997;272(41):25693−25699.
11. Pap T, Müller-Ladner U, Gay RE, Gay S. Fibroblast biology: Role of synovial
fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. 2000;2:361–
367.
12.Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland, JP,
et al. Impaired inflammatory and pain responses in mice lacking an inducible
prostaglandin E synthase. Proc. Natl. Acad. Sci. USA. 2003;100(15):9044−9049.
13.Green JA, Smith GM, Buchta R, Lee R, Ho KY, Rajkovic IA, et al. Circulating
phospholipase A2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis. Inflammation.
1991;15(5);355−367.
14.Bomalaski JS, Baker D, Resurreccion NV, Clark MA. Rheumatoid arthritis synovial fluid phospholipase A2 activating protein (PLAP) stimulates human neutrophil degranulation and superoxide ion production. Agents Actions.
1989:27(3-4);425−427.
15.Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J. Immunol.
1995;154(8):4027−4031.
16.Pope RM. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nature Reviews Immunology. 2002;2:527–535
17.Gauldie J, Hanson JM, Rumjanek FD, Shipolini RA, Vernon CA. The peptide
components of bee venom. Eur. J. Biochem. 1975;61:369–376.
18.Shier WT. Activation of high levels of endogenous phospholipase A2 in cultured
cells. Proc. Natl. Acad. Sci. USA. 1979;76(1):195−199.
19.Koburova KL, Michailova SG, Shkenderov SV. Further investigation on the
anti-inflammatory properties of adolapin-bee venom polypeptide. Acta. Physiol.
Pharmacol. Bulg. 1985;11(2):50−55.
20.Nam KW, Je KH, Lee JH, Han HJ, Lee HJ, Kang SK, et al. Inhibition of COX-2
activity and proinflammatory cytokines (TNFalpha and IL-1beta) production by
water-soluble sub-fractionated parts from bee (Apis mellifera) venom. Arch. Pharm.
Res. 2003;26(5):383−388.
21.Park HJ, Lee SH, Son DJ, Oh KW, Kim KH, Song HS, et al. Anti-arthritic effect
of bee venom: inhibition of inflammation mediator generation by suppression of
NF-kappaB through interaction with the p50 subunit. Arthritis Rheum.
2004;50(11):3504−3515.
22.Hong SJ, Rim GS, Yang HI, Yin CS, Koh HG, Jang MH, et al. Bee venom induces apoptosis through caspase-3 activation in synovial fibroblasts of patients
with rheumatoid arthritis. Toxicon. 2005;46(1):39−45.
23.Loeser JD, Treede RD. The Kyoto protocol of IASP Basic Pain Terminology.
Pain 137 2008;3: 473–477.
24.Furst S. Transmitters involved in antinociception in the spinal cord. Brain Res.
1999;48(2):129−141.
25.Baron R. Mechanisms of disease: Neuropathic pain – a clinical perspective. Nature Clin. Pract. Neuro. 2006;2:95–106.
26.Lee JD, Park HJ, Chae Y, Lim S. An overview of bee venom acupuncture in the
treatment of arthritis. Evid. Based Complement Alternat. Med. 2005;2:79–84.
27.Kwon YB, Kang MS, Kim HW, Ham TW, Yim YK, Jeong SH, et al. Anti-nociceptive effects of bee venom acupuncture (apipuncture) in rodent animal models: a
comparative study of acupoint versus non-acupoint stimulation. Acupunct. Electrother. Res. 2001(b);26(1-2):59−68.
28.Baek YH, Huh JE, Lee JD, Choi do Y, Park DS. Antinociceptive effect and the
mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the
rat model of collagen-induced arthritis: mediation by alpha2-Adrenoceptors. Brain
Res. 2006;1073-1074:305−310.
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Published
2009-01-01
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White, C., & Nezvesky, J. (2009). Bee Venom Therapy: a Sting in the Tale of Rheumatoid Arthritis?. Trinity Student Medical Journal , 10(1), 15–17. Retrieved from https://ojs.tchpc.tcd.ie/index.php/tsmj/article/view/1616
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