Huntington’s Disease: Pathogenesis and Treatment
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1. Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosome. Cell 1993; 72:971-983.
2. Reddy PH, Williams M, Tagle DA. Recent advances in understanding the pathogenesis of Huntington’s disease. Trends Neurosci 1999; 22(6):248-255.
3. Ross CA, Margolis RL. Huntington’s disease. Clin Neurosci 2001; 1:142-152.
4. McMurray CT. Huntington’s disease: new hope for therapeutics. TINS 2001; 24:S32-S38.
5. Bradford HF. Chemical neurobiology: an introduction to neurochemistry. New York: W.H. Freeman & Company, 1986.
6. Cattaneo E, Rigamonti D, Goffredo D. Loss of normal huntingtin function: new developments in huntingtin’s disease research. Trends Neurosci 2001; 24(3):182-188.
7. Cha JJ. Transcriptional dysregulation in Huntington’s disease. Trends Neurosci 2000;
23(9):387-392.
8. Beal MF, Hantraye P. Novel therapies in the search for a cure for Huntington’s disease. Proc Natl Acad Sci USA 2001; 98(1):3-4.
9. Jackel RJ, Maragos WF. Neuronal cell death in Huntington’s disease: a potential role for dopamine. Trends Neurosci 2000; 23:239-245.
10. Schilling G, Coonfield ML, Ross CA, et al. Coenzyme Q10 and ramacemide hydrochloride ameliorate motor deficits in a Huntington’s disease transgenic mouse model. Neurosci Lett 2001; 315(3):149-153.
11. Rigamonti D, Sipione S, Goffredo D, et al. Huntingtin’s neuroprotective activity occurs via inhibition of procaspase-9 processing. J Biol Chem 2001; 276:14545–14548.
12. Freeman TB, Cicchetti F, Hauser RA, et al. Transplanted fetal striatum in Huntington’s disease: Phenotypic development and lack of pathology. Proc Natl Acad Sci USA 2000;
97(25):13877-13882.
13. Bachoud-Levi AC, Remy P, Nguyen JP, et al. Motor and cognitive improvements in patients with Huntington’s disease after neural transplantation. Lancet 2000; 356(9246):1975-1979.
2. Reddy PH, Williams M, Tagle DA. Recent advances in understanding the pathogenesis of Huntington’s disease. Trends Neurosci 1999; 22(6):248-255.
3. Ross CA, Margolis RL. Huntington’s disease. Clin Neurosci 2001; 1:142-152.
4. McMurray CT. Huntington’s disease: new hope for therapeutics. TINS 2001; 24:S32-S38.
5. Bradford HF. Chemical neurobiology: an introduction to neurochemistry. New York: W.H. Freeman & Company, 1986.
6. Cattaneo E, Rigamonti D, Goffredo D. Loss of normal huntingtin function: new developments in huntingtin’s disease research. Trends Neurosci 2001; 24(3):182-188.
7. Cha JJ. Transcriptional dysregulation in Huntington’s disease. Trends Neurosci 2000;
23(9):387-392.
8. Beal MF, Hantraye P. Novel therapies in the search for a cure for Huntington’s disease. Proc Natl Acad Sci USA 2001; 98(1):3-4.
9. Jackel RJ, Maragos WF. Neuronal cell death in Huntington’s disease: a potential role for dopamine. Trends Neurosci 2000; 23:239-245.
10. Schilling G, Coonfield ML, Ross CA, et al. Coenzyme Q10 and ramacemide hydrochloride ameliorate motor deficits in a Huntington’s disease transgenic mouse model. Neurosci Lett 2001; 315(3):149-153.
11. Rigamonti D, Sipione S, Goffredo D, et al. Huntingtin’s neuroprotective activity occurs via inhibition of procaspase-9 processing. J Biol Chem 2001; 276:14545–14548.
12. Freeman TB, Cicchetti F, Hauser RA, et al. Transplanted fetal striatum in Huntington’s disease: Phenotypic development and lack of pathology. Proc Natl Acad Sci USA 2000;
97(25):13877-13882.
13. Bachoud-Levi AC, Remy P, Nguyen JP, et al. Motor and cognitive improvements in patients with Huntington’s disease after neural transplantation. Lancet 2000; 356(9246):1975-1979.
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Published
2003-01-01
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Hosey, A. (2003). Huntington’s Disease: Pathogenesis and Treatment. Trinity Student Medical Journal , 4(1). Retrieved from https://ojs.tchpc.tcd.ie/index.php/tsmj/article/view/1928
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