Multiple Sclerosis – is the Autoimmune Reaction all Smoke and Mirrors?
Keywords:
MedicineAbstract
The most widely accepted hypothesis of MS pathogenesis is the autoimmune hypothesis. Recently, an alternative theory based on neuropathology of acute MS lesions has been proposed that may argue against the autoimmune hypothesis. It suggests that the initial pathology
is oligodendrocyte apoptosis, while the subsequent inflammation that is “autoimmune-like” may in fact be a secondary phenomenon. This new evidence of a potential pathogenesis may have major implications in terms of treatment options. Instead of using Disease Modifying Treatments (DMTs) we can focus on targeting the initial oligodendrogliopathy and therefore halt the progression of disease before it starts.
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